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Generic ZENTICIDE ( Praziquantel ) 600 mg Tablet Patient
Information
For the use of Registered Medical
Practitioner only
ZENTICIDE PRAZIQUANTEL Tablets U.S.P (Film Coated)
ZENTICIDE Tablets 600mg : Colours : Titanium Dioxide USP.
DESCRIPTION: ZENTICIDE (Praziquantel) is
2-cyclohexylcarbony-1,2,3,6,11b-hexahydro-4H-pyrazino-(3,1-a)isoquinoline-4-one.
Generic name: Praziquantel - Oral
Pronunciation: (prazz-ih-KWAN-tull)
M.W.: 312.42
Empirical formula: C19H24N2O2
It is colourless and almost odourless crystalline compound with
bitter taste,
COMPOSITION :
Each tablet contains 600mg of Praziquantel.
INDICATIONS :
ZENTICIDE is effective to all Schistosome species pathogenic to
man includong wide range of Cestodes and liver and lung flukes.
DOSAGE:
Dosage must be adjusted to the individual case by the attending
physician. According to the result obtained so far, the following
dosages are recommended.
Dosage Regimen
Parasites |
Dosage |
Schistosoma haematobium |
20mg/kg x 2 for 1 day |
S. Mansoni |
40mg/kg x 1 for 1 day |
S. Japonicum |
20mg/kg x 3 for 1 day |
Clonorchis sinesis |
25mg/kg x 3 for 1 day |
Opisthorchis viverrini |
25mg/kg x 3 for 1 day |
Paragonimus westermani |
25mg/kg x 3 for 2 day |
P. Heterotremus |
25mg/kg x 3 for 2 day |
The numbers of tablets required for one single
dose can be calculated from the following tablets.
Body weight in (kg) |
No. of tablets(25mg/kg) |
Body weight in (kg) |
No. of tablets
(20mg/kg) |
22-26 |
1 |
20 - 25/26 |
3/4 |
27-33 |
1 1/4 |
26/27 - 33 |
1 |
34-38 |
1 1/2 |
34-41 |
1 1/4 |
39-44 |
1 1/3 |
42-48 |
1 1/2 |
45-50 |
2 |
49-56 |
1 3/4 |
51 -56 |
21/4 |
57-63 |
2 |
57-62 |
21/2 |
64-70 |
21/4 |
63-68 |
2 3/4 |
71 -78 |
21/2 |
69-75 |
3 |
79-86 |
2 3/4 |
ADMINISTRATION :
The tablet should be washed down at once unchewed with some liquid
best after a meal. In case of repeated intake on the same day, the
interval between the individual doses should not be less than 4
and not more than 6 hours. One oblong tablets has three scores.
Each segment contains 150mg active ingredient so that dosage can
be exactly adjusted to the patient's body weight. If 1/4 of a
tablet is required, this is best achieved by breaking the segment
from the other end. Segments are broken off by pressing notch with
thumb nails.
praziquantel
CONTRAINDICATIONS :
None known so far.
PRECAUTIONS:
1. Side Effects: It is mild, transient in nature and tolerable.
Dizziness, headache, drowsiness, nausea, abdominal discomfort,
urticaria, rise in temperature may or may not occur.
2. General Precaution: Side effects are likely to occur more often
after single dose of 40mg/kg and/or in case of a patients with
heavy worm burden. In patients with liver impairment, no
additional adverse effects have occured. For the treatment of
cerebral and ocular cycticercosis, it is necessary to hospitalize
the patient and to secure the attendance of an expert neurologist.
3. During pregnency and breast-feeding; In accordance with the
general rules governing the use of drugs during pregnancy.
ZENTICIDE should not be taken during the first three months of
pregnancy, although animal experiments do not point out to harmful
effects on either pregnant mother animal or unborn baby.
4. A breast-feeding mother can undergo treatment provided her baby
is fed otherwise on the day of treatment and during the subsequent
72 hours.
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Note : This product information is intended only
for residents of the India. Taj Pharmaceuticals Limited,
medicines help to treat and prevent a range of conditions—from the
most common to the most challenging—for people around the world.
Information for Health Care Professionals
Disclaimer: This information should not be used to decide
whether or not to take this medicine or any other medicine. Only
your health care provider has the knowledge and training to
decide which medicines are right for you. This information does
not endorse any medicine as safe, effective, or approved for
treating any patient or health condition. This is only a brief
summary of general information about this medicine. It does NOT
include all information about the possible uses, directions,
warnings, precautions, interactions, adverse effects, or risks
that may apply to this medicine. This information is not
specific medical advice and does not replace information you
receive from your health care provider. You must talk with your
healthcare provider for complete information about the risks and
benefits of using this medicine.
*** Please consult local Prescribing
Information for any product before use. This website is an
international information resource for healthcare professionals
with an interest in disease management. This website is not
intended to replace the advice of a qualified healthcare
professional. Above brand is a trademark of the Taj group of
companies (Taj Pharmaceuticals Limited).
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